A-4 Cartilage Peptide Bioregulator (Sigumir®) 20 Capsules
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Sigumir is a dietary supplement with natural cartilage and bone peptides. Over time, our cartilage can become weaker and less effective, leaving us prone to discomfort and pain through posture deformities and conditions such as rheumatism and arthritis. The joints and spine are often people’s weakest area. Nowadays, even teenagers may experience back pain. However, people over 35 are affected the most—especially women who wear high-heeled shoes and men who do heavy lifting or work at a job with high physical activity. Problems with joints or the spine always occur when people exercise too much or too little. Another group at risk are elderly people, especially women after menopause, because their bone density dramatically decreases. If you’re elderly and you break a bone, your chance of dying shortly afterwards increases. Cartilage and bone tissues are very resistant and do not respond well to corrective measures. This is why it is crucial to support them ahead of time.
Presentation and Pack: Produced in capsules 0.2g each. One pack contains 20 capsules
Ingredients (per 1 capsule): micro crystalline cellulose (E460); beet sugar; sugar; lactose; starch; peptide complex A-4 (cartilaginous peptides)
Daily dose contains: (2 capsules), 20mg of peptide complex A-4 (cartilage peptides)
Contraindications: an individual tolerance of components, pregnancy, lactation
Storage conditions: keep in dry dark place under temperature from +2°C to +25°C
Shelf Life: 5 years from the date of production
Recommendations for application: adult men 1-2 capsules. 1-2 times a day during meals.
Receiving duration: one month
Russian peptide technology was founded during the Cold War years- to help protect elements of the then Soviet forces.
Today Professor Vladimir Khavinson is the President of the European Academy of Gerontology and Geriatrics, but in the 1980’s he was a Colonel in the Soviet Union military medical corps. At the time, he and his team were approached by Kremlin officials, they wanted them to find a way to protect their troops from a myriad of problems; issues such as radiation for submariners in nuclear submarines to troops that may be blinded from known, (but thankfully unused) new weapons such as battlefield lasers.
What their secret research uncovered - that was used for two decades on many thousands of men and women - was a remarkable link between short chain peptides and DNA.
Now their published research is in the open and it identifies that each organ / gland / tissue uses a highly specific short chain peptide to act as a ‘short cut’ to initiate protein synthesis. These peptides can be found in food and unlike proteins they can enter the blood through the stomach. Through a comprehensive list of patents and even copyrighted PowerPoint slides, the Russian research group are showing that each of the concentrated peptide bioregulators so far examined interact with particular strands of DNA - effectively and very specifically activating repair and regenerative processes.
This is a remarkable story since what we are describing here are individualised gene switches and since they have been tested for many years on thousands of individuals, without report of any serious side effects or contraindications to date, they could be set to ‘out do’ stem cells. Why? Because this peptide therapy is relatively cheap, highly specific, can be taken orally and doesn’t require any suppression of the immune system to operate fully.
Professor Khavinson and his award winning team at the St Petersburg Institute of Biogerontology have discovered that each organ / gland has a biological reserve and despite the origin of the tissue they have studied, incredibly each one is always set at 42%
What is a peptide bioregulator?
A peptide is a short chain of amino acids, identified by the fact that it is shorter than a protein, and so can be absorbed easily via the digestive system. Each organ or bodily function has its own unique peptide bioregulator. Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active. In other words, peptides do not treat, they promote the natural repair of damaged organs.
For many years the peptide preparations were available only as medicines, in the form of injections. However some years ago Prof. Khavinson and the Russian St. Petersburg Institute of Bioregulation and Gerontology created dietary supplements that can also reduce peptide deficiency and restore peptide-protein cycle in cells. They can be divided into natural (Cytomaxes) and synthesized (Cytogens) russian peptide bioregulators.
Natural russian peptide bioregulators (Cytomaxes)
Natural russian peptide bioregulators is a group of peptides of less than 50 amino acids and with a molecular mass of less than 5 kDa, free from foreign DNA or protein substance, extracted from organs and tissues of young calves by a patented method of thorough filtering. 5 kDa is very little. The molecular mass of DNA fragments and proteinaceous infectious particles, the prions, are several times bigger than that. Therefore these natural russian peptide supplements are extremely clean products. They do not have any immunogenic or mutagenic properties.
Inside the gastrointestinal tract the natural russian peptide bioregulators break down into amino acids and di-, tri- and tetrapeptides that match the DNA in a complementary way and activate protein synthesis in the respective body system. Their performance is gentle and gradual. Their effect continues to grow even after finishing the supplementation course and lasts up to 4-6 months until the peptide-protein cycle is impaired again.
Synthesized peptide bioregulators (Cytogens)
The analysis of natural peptides was used to detect the most active peptide from a group, which was later replicated in a lab. Synthesized (Cytogens) peptide bioregulators supplement contains only one peptide molecule whereas natural one includes a group of molecules. Synthesized peptides have an immediate impact compared to natural peptides and have a faster, yet more short-lived effect (1.5-2 months). Such peptides are typically used to start the initial peptide deficiency treatment. However, it is advised to switch to natural (Cytomaxes) peptides as a follow-up course.
Both types of peptides are efficient, safe to use, have no side effects and are compatible among themselves and with other products. As for the choice between natural and synthesized russian peptides, it depends on a particular situation. However, in most cases synthesized peptides, if available, are administered prior to the use of natural peptides.
Disclaimer: Please note that only your own physician can determine your precise needs, but in order to give you some information these answers are based upon the ‘average person’ and clinical/ published results.
What is a peptide bioregulator?
A peptide is a short chain of amino acids, identified by the fact that it is shorter than a protein, and so can be absorbed easily via the digestive system. Each organ or bodily function has its own unique peptide bioregulator.
Peptide bioregulators have been shown to shortcut the protein synthesis process by interacting directly with cell DNA – meaning that organs can build and repair tissues easier and quicker when peptide bioregulators are active.
What combination of peptides would be best to consider for the elderly in general?
Glandokort® - adrenal peptide, Vladonix® -thymus peptide and Ventfort® - blood vessels peptide.
Would there be a difference between dosing for men and women?
Not particularly, the dosing is more related to need than sex or body weight
Is it best to include the blood vessel peptide in all combinations used?
Yes it is recommended, the blood vessel peptide is known as Ventfort®
What is the typical dosing regimen for the peptides in general?
Two capsules a day for 10-days - a total of 20 capsules equivalent to one pack - for general support this can be repeated again in 6-months’ time, if the need is greater then it can be repeated again in 2 to 3 months’ time, if the need is felt to be great then typically the regimen is repeated every month.
How many peptide complexes can I take at the same time?
You can combine up to 5 peptide complexes at the same time.
What are the side effects?
15 million people have undergone the peptide treatment for 30 years and no side effects have been found. The fact is that peptides in animals and humans are identical and our body sees them as its own. Peptides only normalize the protein synthesis and they are not able to overstimulate it.
Are there any contraindications?
Individual intolerance to the components, pregnancy and breastfeeding.
Can I take peptides with other supplements too?
Yes, you can.
How can I be sure that peptides have an actual effect on me?
Sometimes it can be hard to notice changes subjectively, so an objective method can be helpful. Ask your doctor what tests could be done to assess your current health condition. Do them before and after taking appropriate peptides
Why aren't there any similar peptide complexes from other companies?
First of all, the process of extracting peptides is patented. Secondly, Russian scientists started working on this class of medical substances 40 years ago at the request of the military, therefore they had access to all necessary funds. There were a 30-year study on rats, a study on apes and clinical trials. Nowadays just a few researches can be funded so well to be conducted on the same large scale.
Can Endoluten be consumed alongside any other supplements?
As they are each tailored to a specific gene, there is no problem with consuming multiple supplements at one time.
Can Endoluten be used to regulate sleep?
As it promotes melatonin secretion, Endoluten could be used to encourage a regular sleep pattern
Are there any known side effects for using this supplement?
Ventfort has been tested for many years on thousands of individuals, without reports of any serious side effects.
What combination of peptides should i take?
According to Prof. Vladimir Khavinson, the president of European Association of Gerontology and Geriatrics, the first class combination consists of Endoluten (Neuro-endocrine system), Vladonix (Immune system), Cerluten (Brain), Sigumir (Joints and Bones), Svetinorm (Liver) and Ventfort (Blood vessels) for one or two months twice a year. Endoluten and Vladonix are the two most important geroprotector that are able to extend life by 30-40%.
Here are some general recommendations:
Natural Peptides Combinations
Aging and protein synthesis
Aging is a major risk factor for disease and death but what is the cause of aging? Despite many theories it is still unknown. What we know is that as we age our body produces fewer proteins that have a large number of important functions in our body. For example:
Basically, our bodies make thousands of specific proteins that serve important roles in everyday functioning — in fact, the human body is about 45% protein on a dry matter basis.
As aging is associated with a decline in the synthesis of protein, it is logical to assume that if the synthesis is restored aging can be slowed down. As it turns out this assumption is correct. Scientists V. Khavinson and V. Morozov have found a way to repair protein production and have achieved incredible results. Using the following methods can increase lifespan by 20-40%
The information about different proteins is stored in the DNA. In order to launch protein synthesis a DNA fragment, a gene, has to be activated by triggering molecules, peptides. Peptides are relatively short chains of amino acids and they are an essential part of the cell self-regulating mechanism:
Cells constantly degrade aged proteins by breaking them down into amino acids and peptides. Some of these peptides match specific parts in the cell DNA following the lock-key principle. As a result, the peptide resumes the synthesis of the protein from which it was originally built. When the protein ages, it is fragmented into the same peptides once again. All of this forms a circular process that is vital to cell life.
However, due to extended exposure to environmental hazards and stress this cell self-regulating mechanism is compromised and we become peptide deficient. Peptide deficiency leads to cell malfunction and eventually to diseases and premature aging. Luckily, we can restore the peptide-protein cycle with peptide supplements.
The first peptide product was created for the military in the Russian Military Medical Academy 40 years ago in 1974 by V. Khavinson and V. Morozov since 1977 and it has been authorized for clinical use under the name Thymalin. It cointains thymus peptides, extracted from young calves, that restore the impaired immune system and minimize the risk of cancer by several times. Shortly, Epithalamin, a product formulated with the pineal gland peptides was developed. It prevents premature aging, improves the function of the endocrine, immune, cardiovascular and reproductive systems, lengthens telomeres, restores carbohydrate metabolism, and strengthens bones and joints. It was proven that if administrated together the pineal gland and the thymus peptides can prolong human life substantially. Their high efficiency has been shown in more than 50 experiments on animals and multiple clinical trials in the last 40 years.
Eventually, peptides have been extracted from almost every body system and demonstrated stunning tissue-specific properties, i.e., they have beneficial effects on the organs which they were extracted from.
In the last 40 years these medicines have been taken by more than 15 millions of people and no side effects have been found. The fact is that peptides are apparently evolutionary the oldest cell self-regulating mechanism and as their structure is quite simple they have not undergone any constructional changes over time. That means that peptides in animals and humans are identical. Besides it was also proven that peptide intake can only normalize the protein synthesis and cannot overstimulate it as a cell cannot take more peptides than it needs.
For many years the peptide preparations were available only as medicines, in the form of injections. However some years ago Prof. Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology created dietary supplements that can also reduce peptide deficiency and restore peptide-protein cycle in cells. They can be divided into natural and synthesized peptides.
Natural peptides (Cytomaxes)
Natural peptides is a group of peptides of less than 50 amino acids and with a molecular mass of less than 5 kDa, free from foreign DNA or protein substance, extracted from organs and tissues of young calves by a patented method of thorough filtering. 5 kDa is very little. The molecular mass of DNA fragments and proteinaceous infectious particles, the prions, are several times bigger than that. Therefore these peptide supplements are extremely clean products. They do not have any immunogenic or mutagenic properties.
Inside the gastrointestinal tract the natural peptides break down into amino acids and di-, tri- and tetrapeptides that match the DNA in a complementary way and activate protein synthesis in the respective body system. Their performance is gentle and gradual. Their effect continues to grow even after finishing the supplementation course and lasts up to 4-6 months until the peptide-protein cycle is impaired again.
When and how to take peptides?
It is advised to start taking peptide supplements upon reaching 35 years of age as a preventive measure against premature aging. At this stage two to three 10-day courses of the basic products per year are sufficient to maintain the body's well-being. These basic products are Vladonix, Cerluten, Ventfort, Sigumir, Svetinorm and if a person works night shifts or often takes intercontinental flights, Endoluten. They regulate the function of the systems that age faster. If required, other peptides could be added as another ten-day course, based on individual needs.
Starting from 40-45 years, two courses a year become necessary, with 2 capsules daily for 30 days per course. The health in the decades to follow will majorly be influenced by the degree of recovery achieved during this period. It is crucial to start timely biannual intake of extensive anti-age courses that include Endoluten, Vladonix, Cerluten, Ventfort, Sigumir, Svetinorm, Chelohart and for men Libidon, Testoluten, for women Zhenoluten and Thyreogen. Additional products are chosen based on individual needs and predispositions. Generally, the older we get, the more organs that require additional support.
Starting from 50-55 years, it is generally recommended to increase the number of courses a year from two to three. If you need to take more than 5 peptide products it is usually advised to split the course in several months so that each month you take 5 products or fewer. Please note for better absorption peptides are taken 30 minutes before meals.
There is still no way to stop aging but thanks to the scientists' intensive work during the last 40 years, we finally have dietary supplements that substantially slow down aging by reducing peptide deficiency and restoring cell peptide-protein cycles in the body. There are 19 natural peptide products and 12 synthesized ones that cover almost every body system and organ. Thus, if you want to live longer being mentally and physically healthy you have now a real solution.
Please note: You should always consult a primary care physician/health practitioner of choice when considering the use of any products for health purposes, especially when undergoing treatment for an existing condition.
Warning: Keep out of direct light. Do not contaminate or touch fluid in bottle. If you are pregnant, nursing, or taking any medication, consult your doctor before use. Discontinue use and consult doctor if any adverse reactions occur. Not intended for use by person under the age of 18. Keep out of reach of children. Store in a dry place and avoid excessive heat.
Disclaimer: These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or healthcare professional. You should not use the information contained herein for diagnosing or treating a health problem or disease, or prescribing medication.
The information on this website is for informational and educational purposes only. It is not an attempt by the writers or publisher to diagnose or prescribe, nor should it be construed to be such. The information is not intended to replace medical advice offered by physicians. Readers are hereby encouraged to consult with a licensed health care professional concerning the information presented, which has been received from sources deemed reliable, but no guarantees, expressed or implied, can be made regarding the accuracy of same. Therefore, readers are also encouraged to verify for themselves and to their own satisfaction the accuracy of all reports, recommendations, conclusions, comments, opinions, or anything else published herein before making any kind of decisions based upon what they have read. If you have a medical condition, please consult your medical practitioner. Vita Stream, INC will not be liable for any direct, indirect, consequential, special, exemplary, or other damages arising from the use or misuse of any products, materials or information published